Rev Esp Enferm Dig. 2022 May 12. doi: 10.17235/reed.2022.8897/2022. Online ahead of print.

Migration of hem-o-lok clips to the rectum after laparoscopic radical prostatectomy (LRP) is rare. Only two cases have reported this phenomenon, both of which were found to have one end of the Hem-o-lok clip protruding into the rectal lumen during regular colonoscopy. So it was easier to diagnose and treat. Here we report a case of a 61-year-old patient who underwent LRP for prostate cancer. And Hem-o-lok clips were used for the ligation of the neurovascular bundle during LRP. Migration of the Hem-o-lok clip into the rectal submucosa occurred three years after LRP and was successfully diagnosed and treated by Endoscopic submucosal dissection (ESD). Based on this case, we suggest that clinicians should be aware of the phenomenon of intestinal submucosal lesions caused by surgical clip migration, and ESD is a feasible treatment for it.